At Renue By Science, we don't just follow the latest supplement trends. We study the underlying biochemistry of aging and identify compounds with the strongest clinical evidence for safety and efficacy. Our research team continuously monitors the scientific literature -- from Nature and Cell to specialized journals in gerontology and molecular biology -- to stay at the forefront of longevity science.
Our products target the key hallmarks of aging identified by the scientific community: mitochondrial dysfunction, cellular senescence, NAD+ decline, epigenetic alterations, genomic instability, and loss of proteostasis. By addressing multiple pathways simultaneously, we aim to support comprehensive cellular health.
NAD+ is an essential coenzyme for cellular energy production and DNA repair. Levels decline by up to 50% between ages 40-60. NMN and NR are direct NAD+ precursors that have been shown to restore NAD+ levels in multiple human clinical trials, supporting mitochondrial function, sirtuin activation, and healthy aging.
Fisetin is a naturally occurring flavonoid found in strawberries and apples. It acts as a senolytic -- a compound that selectively clears senescent ('zombie') cells that accumulate with age and secrete inflammatory factors. Preclinical studies show fisetin reduces senescent cell burden and extends healthspan in animal models.
Resveratrol and its more bioavailable analog pterostilbene activate sirtuins -- a family of proteins that regulate cellular health and longevity. SIRT1 activation mimics some effects of caloric restriction, supporting metabolic health, cardiovascular function, and mitochondrial biogenesis.
Berberine is an alkaloid that activates AMPK -- often called the 'metabolic master switch.' Through AMPK activation, berberine supports healthy blood glucose metabolism, lipid profiles, and cardiovascular function. Multiple RCTs have shown berberine's effects are comparable to pharmaceutical interventions for metabolic health.
Glutathione is the body's most abundant endogenous antioxidant, critical for detoxification, immune function, and cellular redox balance. Levels decline with age, oxidative stress, and environmental toxin exposure. Supplementation supports liver detoxification pathways and protects cells from oxidative damage.
Coenzyme Q10 is an essential component of the mitochondrial electron transport chain, where it facilitates ATP production. It also functions as a lipid-soluble antioxidant in cell membranes. CoQ10 levels decline significantly after age 40, and supplementation has been shown to support heart health, energy levels, and exercise performance.